Alpha-Glucosidase Inhibitors: Acarbose (Precose) and Miglitol (Glycet)

Alpha-glucosidase inhibitors are type 2 diabetes medications. It’s the parent group of two medicines: Acarbose Precose and Miglitol Glyset. These medications help the regulation of your blood sugar and prevent it from elevating too quickly after a meal. If you’re a type 2 diabetic patient, an alpha-glucosidase inhibitor is one of the treatment options your doctor may prescribe for you.

ZipRX offers Acarbose (Precose) and Miglitol Glyset.

Acarbose for Hypoglycemia

Hypoglycemia usually occurs when you overdose on insulin or get your insulin shot and skip eating. Symptoms of hypoglycemia include sympathetic nervous system stimulation and altered mental status. If there’s a case of hypoglycemia while you’re using Acarbose, take any of the below options:

  • One tablespoon of honey

  • One cup of milk

  • Four tablets of dextrose

Processed sugar such as sugar candy, table sugar, and carbonated drinks increase blood sugar levels, but this won’t work if you’re using Acarbose.

Acarbose Precose Side Effects

The side effects commonly experienced while using this medication include:

  • Gas

  • Diarrhea

  • Upset stomach

  • Bloating

  • Stomach pain during the initial period of treatment (because your body is adjusting to the medication, it usually gets better over time)

  • Itching and skin rash

Severe side effects

There are other instances where severe side effects can show up. They rarely happen. They include:

  • Dark urine

  • Severe pain in the abdomen or stomach

  • Consistent vomiting

  • Jaundice

  • Rectal bleeding

  • Abnormal fatigue

  • Constipation

  • Diarrhea

  • Easy bruising

If you’re experiencing any of these side effects, contact your doctor for emergency medical assistance.

Acarbose Contraindications

It’s not advisable to use this medication if you have or have had certain medical conditions. It is best to inform your doctor about this condition so he/she can prescribe an alternative medication. These conditions are listed below:

  • Diabetic ketoacidosis

  • Hypersensitivity

  • Inflammatory bowel disease

  • Liver cirrhosis

  • Colonic ulceration

  • Intestinal blockage or being prone to intestinal blockage

  • Digestion or absorption complications

  • Chronic intestinal disease

  • Any medical condition that will get worse because of the enhanced formation of gas in the intestine

Visit here to buy Acarbose (Precose).

Miglitol Glyset Mechanism of Action

Glyset functions differently from sulfonylureas drugs because it doesn’t boost the secretion of insulin. Instead, it’s anti-hyperglycemic because of an undoable restriction of membrane-bound intestinal α-glycoside hydrolase enzymes. These enzymes hydrolyze disaccharides and oligosaccharides into glucose at the border of the small intestine.

This inhibition triggered by the enzymes slows down glucose absorption and reduces postprandial hyperglycemia in type 2 diabetes patients. The way Glyset functions differently from sulfonylureas by boosting glycemic control makes them a good combination. Glyset will offset the weight-gain and insulinotropic effects of using sulfonylureas when used together.

Miglitol is known for having a minor inhibitive effect on lactase. This means using Miglitol according to the prescribed or inscribed doses shouldn’t trigger lactose intolerance.

Miglitol Indications

Miglitol shouldn’t be used for the treatment of type 2 diabetes if you have the following conditions:

  • Hypersensitivity or an allergic reaction to the medication or any of its ingredients

  • Colonic ulceration

  • Inflammatory bowel disease

  • Partial intestinal blockage or predisposition to intestinal blockage

  • Diabetic ketoacidosis

  • Chronic intestinal diseases (digestive or absorption disorder and any condition that will worsen because of more formation of gas in the intestine)

Miglitol Glyset Side Effects

Commonly experienced side effects while using this medication include:

  • Stomach upset

  • Abdominal or stomach pain

  • Gas

  • Diarrhea

  • Skin rash

  • Iron deficiency anemia

These side effects usually occur within your first month of treatment. The reason is your body is still getting used to this medication. Over time, these effects will subside.

Glyset on its own doesn’t trigger hypoglycemia, which is low blood glucose. Still, combining Glyset with other diabetic medications and not eating enough food could cause hypoglycemia.

So how do you know you’re experiencing hypoglycemia? These symptoms could be indicators:

  • Blurry sight

  • Dizziness

  • Fever

  • Sweating

  • Hand and/or feet tremors

  • Fainting

  • Fast heart rate

  • Hunger

To start treating type 2 diabetes, order for Acarbose (Precose) or Miglitol (Glyset) on ZipRX.


Alpha-glucosidase inhibitors are type 2 diabetes medications. Acarbose Precose and Miglitol Glyset are alpha-glucosidase inhibitors that help the regulation of your blood sugar and prevent it from elevating too quickly after a meal.

Education about what you need to control diabetes:

The doctor will determine which medication is ideal for someone’s condition as there are different factors that can impact which medication will be more effective such as contraindications, medical history, and allergies.

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