Tiotropium+Olodaterol, Stiolto Respimat/Inspiolto Respimat
Description: Anticholinergic, Beta agonist, long-acting, inhalant (oral)
Brand Name US: Stiolto
Canadian Equivalent: Inspiolto
CSA NA – FDA Approved – REMS (N) – Can Ship
How Does It Work
Tiotropium is an anticholinergic agent that is a reversible competitive inhibitor of type 3 muscarinic (M3) receptors which cause the smooth muscle in the bronchi to relax and subsequently lead to bronchodilation.
Olodaterol is a selective beta-agonist that binds to beta2 receptors located on the bronchial smooth muscle causing the airway to dilate reducing the work required to breathe while having little effect on heart rate.
Indications For Use
Chronic obstructive pulmonary disease
Before starting Tiotropium+Olodaterol, Stiolto Respimat/Inspiolto Respimat make sure your physician is aware of any allergies or medications you currently take. Hyperthyroidism, cardiovascular disease, electrolyte disturbances, urinary retention, and rare paradoxical cases of life-threatening bronchospasm have been reported.
Oral Inhalation: Soft Mist Inhaler
Take two inhalations once daily (maximum: 2 inhalations per day.)
Pharmacist Tips On Using
How to Take Tiotropium+Olodaterol, Stiolto Respimat/Inspiolto Respimat
Administer at the same time each day. Prime inhaler prior to initial use or if not used for >21 days by pointing inhaler towards the ground and actuating until an aerosol cloud is seen, then repeat 3 additional times before use. If not used for >3 days (but ≤21 days), actuate once before use. To prepare the inhaler for use after priming, refer to manufacturer labeling. When the dose is ready to be administered, breathe in slowly through the mouth and press the dose release button; continue to breathe in slowly as long as possible, then hold breath for 10 seconds or for as long as comfortable. Repeat for the second inhalation.
Nasopharyngitis, cough, muscle, and joint pain
Note this is not a complete list of side effects for Tiotropium+Olodaterol, Stiolto Respimat/Inspiolto Respimat only common ones
Frequently Asked Questions
Why is my heart racing/ am I stimulated after using Tiotropium+Olodaterol, Stiolto Respimat/Inspiolto Respimat?
Olodaterol works on specific adrenaline receptors however it sometimes will activate other adrenaline receptors that results in increased heart rate/ mental stimulation
Why does one brand of inhaler feel differently than another?
Different brands of metered-dose inhalers may use different propelling agents and dry powder inhalers have such a small amount of powder dispensed you likely will not feel it