Description: Antineoplastic Agent, Cyclin-Dependent Kinase Inhibitor
CSA NA – FDA Approved – REMS (N) – Can Ship
How Does It Work
Palbociclib, Ibrance a cyclin-dependent kinase (CDK) inhibitor which is selective for CDK 4 and 6. Palbociclib, Ibrance inhibits the CD4/6 pathways which reduce the proliferation of breast tumour cells by preventing progression from the G1 to the S cell cycle phase.
Indications For Use
Breast cancer, advanced
Before starting Palbociclib, Ibrance makes sure your physician is aware of any allergies or medications you currently take. Palbociclib, Ibrance has been known to cause bone marrow suppression, gastrointestinal toxicity (i.e. nausea, vomiting, diarrhea, and stomatitis) and pulmonary toxicity.
Oral: 125mg daily for 21 days, then 7 days off.
Pharmacist Tips On Using
How to Take:
Oral: Administer at approximately the same time each day. Swallow whole do not crush or chew; do not split tablets or open capsules prior to swallowing (do not ingest if tablets or capsules are broken, cracked, or not intact).
Tablets: Administer with or without food.
Capsules: Administer with food.
Palbociclib, Ibrance fatigue, alopecia, skin rash, xeroderma, nausea, stomatitis, diarrhea, elevated liver enzymes, infection, asthenia, fever.
Note this is not a complete list of side effects for Palbociclib, Ibrance only common ones.
Frequently Asked Questions
Why would my physician prescribe a medication with such serious side effects?
Your physician takes the most recent clinical guidelines to make evidence-based decisions on what medication is appropriate in which situations. Your current medications, your allergies, age, cost of medication, comorbid conditions and many other factors will further complicate or limit which medications are appropriate. This medication is used for certain forms of cancer and your physician has determined the benefits outweigh the risks. Furthermore, they will be monitoring your bloodwork and symptoms closely to avoid many of the serious side effects and will keep you on the lowest effective dosage for the shortest amount of time possible.