Description: Antineoplastic Agent, Epidermal Growth Factor Receptor (EGFR) Inhibitor, Tyrosine Kinase Inhibitor
CSA NA – FDA Approved – REMS (N) – Can Ship
How Does It Work
Dacomitinib, Vizimpro is an irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor which has activity against EGFR/HER1, HER2, and HER4, as well as some EGFR-activating mutations (exon 19 deletion or exon 21 L858R substitution mutation). Dacomitinib, Vizimpro displays antitumor activity against by inhibiting autophosphorylation against HER family targets including mutated EGFR.
Indications For Use
Non-Small Cell Lung Cancer
Before starting Dacomitinib, Vizimpro make sure your physician is aware of any allergies or medications you currently take. Dacomitinib, Vizimpro causes dermatologic toxicity, gastrointestinal toxicity and pulmonary toxicity. Prior to using Dacomitinib, Vizimpro confirm the presence of epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R mutations in tumor specimen prior to therapy initiation.
Oral: 45mg once daily.
Missed doses: If a dose is missed or vomited, do not make up the missed/vomited dose; administer the next dose as scheduled.
Pharmacist Tips On Using
Oral: Take at the same time each day with or without food. Avoid the concomitant use of proton pump inhibitors with dacomitinib. If using an H2 blocker or antacid, administer Dacomitinib, Vizimpro at least 6 hours before or 10 hours after the H2 blocker or antacid.
Chest pain, insomnia, skin rash, paronychia, xeroderma, alopecia, pruritis, dermatitis, electrolyte disturbances (i.e. hypocalcemia, hypokalemia, hyponatremia, hypomagnesemia), hyperglycemia, hypoalbuminemia, diarrhea, stomatitis, nausea, constipation, oral mucosa ulcer, anemia, lymphocytopenia, elevated liver enzymes, conjunctivitis, cough, dyspnea, upper respiratory tract infection.
Note this is not a complete list of side effects for Dacomitinib, Vizimpro only common ones.
Frequently Asked Questions
Why would my physician prescribe a medication with such serious side effects?
Your physician takes the most recent clinical guidelines to make evidence-based decisions on what medication is appropriate in which situations. Your current medications, your allergies, age, cost of medication, comorbid conditions and many other factors will further complicate or limit which medications are appropriate. This medication is used for certain forms of cancer and your physician has determined the benefits outweigh the risks. Furthermore, they will be monitoring your bloodwork and symptoms closely to avoid many of the serious side effects and will keep you on the lowest effective dosage for the shortest amount of time possible.