Description: Thrombolytic Agent
CSA NA – FDA Approved – REMS (N) – Can Ship
How Does It Work
Tenecteplase, TNKase promotes initiation of fibrinolysis by binding to fibrin and converting plasminogen to plasmin.
Indications For Use
ST-elevation myocardial infarction
Before starting Tenecteplase, TNKase makes sure your physician is aware of any allergies or medications you currently take, if you have an active bleed, previous cerebrovascular/cardiovascular event, history of aneurysm, any other conditions that increase bleeding risk, are pregnant, or breastfeeding. Tenecteplase, TNKase use has been associated with rare but serious adverse events such as arrhythmia, bleeding, cholesterol embolization, hypersensitivity reaction, and thromboembolic events.
IV: The recommended total dose should not exceed 50 mg and is based on weight.
Pharmacist Tips On Using
How to Take: Administer as a single bolus over 5 seconds. Thrombolytic should be administered within 30 minutes of hospital arrival. Generally, there is only a small trend for benefit of therapy after a delay of 12 to 24 hours from symptom onset, but thrombolysis may be considered for selected patients with ongoing ischemic pain and extensive ST elevation. Administer concurrent aspirin, clopidogrel, and anticoagulant therapy. Store under refrigeration of 2°C to 8°C (36°F to 46°F) or at room temperature; do not exceed 30°C (86°F). If reconstituted and not used immediately, store in the refrigerator and use within 8 hours.
You Need to Avoid: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance so avoid starting any new medications without consulting the prescriber. Tenecteplase is incompatible with dextrose solutions. Dextrose-containing lines must be flushed with a saline solution before and after administration. Avoid IM injections and nonessential handling of patients.
Note this is not a complete list of side effects, only the most common