Conjugated Estrogen (Oral), Premarin
Description: Estrogen Derivative
“Alert: US Warning
There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Adding progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer.
Estrogen-alone therapy should not be used for the prevention of cardiovascular disease. Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease.
The WHI estrogen-plus-progestin study demonstrated an increased risk of invasive breast cancer.
Estrogen-alone therapy should not be used for the prevention of dementia. Estrogen plus progestin therapy should not be used for the prevention of dementia.”
CSA NA – FDA Approved – REMS (N) – Can Ship
How Does It Work
Premarin contains a mixture of sodium salts and estrogen conjugates (estrone sulphate, equilin sulphate, 17 alpha-dihydroequilin, 17 alpha-estradiol and 17 beta-dihydroequilin). Estrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Premarin is used in menopausal hormone therapy and for various other conditions.
Indications For Use
Breast cancer (metastatic), hypoestrogenism, prevention of osteoporosis, prostate cancer (advanced), vasomotor symptoms and vaginal atrophy associated with menopause
Before starting Conjugated Estrogen, Premarin make sure your physician is aware of any allergies or medications you currently take, and activities you perform. Conjugated Estrogen, Premarin when used with progestin can increase the risk of invasive breast cancer in post-menopausal women. Unopposed Premarin usage in women with an intact uterus can increase the risk of endometrial cancer. Conjugated Estrogen, Premarin can exacerbate endometriosis and may cause retinal vascular thrombosis. Conjugated Estrogen, Premarin should be used with caution in patients with familial defects in lipoprotein metabolism, asthma, diabetes, cardiac and renal dysfunction, epilepsy, cholestatic jaundice, hypoparathyroidism, migraine, porphyria, systemic lupus erythematosus, and hepatic hemangiomas. Conjugated Estrogen, Premarin is contraindicated in women with active DVT, PE, arterial thromboembolic disease (stroke and MI), or a history of these conditions.
Usual (Oral): 0.3mg to 0.625mg daily which may be given cyclically; adjust dose according to the severity of symptoms and patient response.
Note: Either 3 weeks on, 1 week off or 25 days on, 5 days off.
Pharmacist Tips On Using
How to Take Conjugated Estrogen (Oral), Premarin: Take without regard to meals, same time each day.
Headache, abdominal pain, vaginal hemorrhage, mastalgia, back pain, arthralgia, pharyngitis, sinusitis, depression, dizziness, diarrhea, flatulence, vaginitis, leukorrhea, vulvovaginal candidiasis, weakness, leg cramps, increased cough
Note this is not a complete list of side effects, only the most common.
Frequently Asked Questions
What do I do if the side effects are not tolerable?
If the side effects are causing a lot of distress speak to our physician as soon as possible to discuss options.