Description: Antibiotic, Tetracycline Derivative
CSA NA – FDA Approved – REMS (N) – Can Ship
How Does It Work
Minocycline inhibits protein synthesis by binding with the 30S and possibly the 50S ribosomal subunit(s) of susceptible bacteria; may also cause alterations in the cytoplasmic membrane. Minocycline also inhibits microglial activation and pro-inflammatory cytokine release. Minocycline has been shown to have neuroimmune modulatory properties that promote remyelination and improves cognition and memory following injury.
Indications For Use
Officially indicated as an antibiotic for various bacterial infections. It is sometimes used off-label for neuroinflammation.
Can cause esophagitis and ulcerations
Discontinue use in patients who experience a hypersensitivity syndrome, renal impairment, intracranial hypertension
Can cause photosensitivity and tissue hyperpigmentation
Oral: Take as directed by a medical doctor; never exceed the maximum recommended daily dose.
Points To Consider
Pharmacist Tips On Using
How Do You Use Minocycline: Take minocycline with food to reduce gastrointestinal symptoms. Take with a full glass of water and do not lie down for at least 30 minutes after taking to reduce the risk of esophageal irritation and ulceration.
Is Minocycline Safe to Use During Pregnancy: Minocycline has in rare cases been linked to congenital anomalies. Due to a limited amount of information, a causal relationship has not been established. However, tetracyclines as a class should generally be considered a second-line antibiotic in pregnant women and their use should be avoided.
Well tolerated, most side effects are transient and mild to moderate in nature. The most common side effects include:
Dermatologic: Pruritus (5%), urticaria (2%)
Nervous system: Dizziness (9%), fatigue (9%), malaise (4%), drowsiness (2%)
Neuromuscular & skeletal: Arthralgia (1%)
Otic: Tinnitus (2%)