Description: Antidiabetic Agent, Biguanide, Dipeptidyl Peptidase 4 (DPP-4) Inhibitor
“Alert: US Warning
Metformin has been associated with lactic acidosis resulting in death, hypothermia, hypotension, and arrhythmias. If metformin-associated lactic acidosis is suspected, immediately discontinue medication and institute general supportive measures. Prompt hemodialysis is recommended.”
CSA NA – FDA Approved – REMS (N) – Can Ship
How Does It Work
Kazano is a combination drug that contains metformin and alogliptin which control blood glucose levels. Metformin decreases the production of glucose from the liver, reducing intestinal absorption of glucose and improves insulin sensitivity. Alogliptin inhibits dipeptidyl peptidase 4 (DPP-4) enzymes which increases incretin hormone levels that increase insulin synthesis and release from the pancreas while reducing glucagon secretion.
Indications For Use
Type 2 Diabetes
Before starting Metformin+Alogliptin, Kazano makes sure your physician is aware of any allergies or medications you currently take, and activities you perform. Metformin+Alogliptin, Kazano have been associated with arthralgia, bullous pemphigoid, hypersensitivity reactions including Stevens-Johnson syndrome, lactic acidosis, pancreatitis, vitamin B12 deficiency, and worsening renal function. Metformin+Alogliptin, Kazano should not be used in patients with heart failure and/or hepatic impairment.
Usual (Oral): Initial dose of alogliptin 12.5mg/metformin 500mg to 1g twice daily. A maximum daily dose of alogliptin 12.5mg/metformin 1g twice daily.
Note: Due to the lack of additive glycemic benefit, the use of alogliptin in combination with a glucagon-like peptide-1 (GLP-1) receptor agonist should be avoided. May require a dose reduction of insulin and/or insulin secretagogues to avoid hypoglycemia.
Pharmacist Tips On Using
How to Use: Take with meals, at the same time each day. Swallow the tablet whole, do not break, crush, or chew.
Headache, hypoglycemia, diarrhea, urinary tract infection, back pain, upper respiratory tract infection, nasopharyngitis
Note this is not a complete list of side effects, only the most common.
Frequently Asked Questions
What do I do if the side effects are not tolerable?
If the side effects are causing a lot of distress speak to our physician as soon as possible to discuss options.